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A 12-month (renewable) research position is available for a motivated individual to take part
in a multidisciplinary project focusing on carbon nanoparticles (carbon nanodots), their
interactions with the respiratory tract, and their potential as a platform for nanomedicine and
theranostics. The rapid development of nanotechnologies (e.g. for the production of
manufactured goods, medicines, cosmetics…) results in increasing exposure of individuals to
various nanoparticles. The nanometric size provides these particles with unprecedented
properties that are still poorly characterized and understood, and that may raise some concerns
in terms of public health, particularly respiratory health. Indeed, numerous in vivo and in vitro
studies have suggested that engineered nanoparticles exhibit inflammatory and pro-allergizing
effects on the respiratory system. However, many contradictory results have been reported in
the literature. This could be related to the wide variability of the investigated nanoparticles in
terms of size, charge, or surface chemistry. Thus, using a model nanoparticle, namely carbon
nanodots*, we propose to investigate to what extent the physicochemical characteristics are
likely to modulate the inflammatory and pro-allergizing activity of the nanoparticles in the
respiratory tract. This work will be conducted in vitro (airway epithelial or dendritic cells,
macrophages) and in vivo (mice), using various technical approaches including molecular
biology (RT-qPCR, western blot, ELISA), FACS analysis, and fluorescence and electron
microscopy.
*These nanoparticles are otherwise subjected to developments in our research group for the
production of new drug delivery systems and theranostic platforms.
Required skills: PhD in life and health sciences ; knowledge in nanomedicine/nanotoxicology
and/or lung physiopathology (inflammation, fibrosis, asthma, BPCO) ; expertise in cell
culture and animal experimentation, FACS and molecular biology techniques.
Applications (CV including a list of publications, a brief summary of research experience and
technical skills, and names and full contact details of 2 referees) should be sent to :


Pr F. Pons, Laboratoire de Conception et Application de Molécules Bioactives - UMR 7199
CNRS - Université de Strasbourg - Faculté de Pharmacie, 74 route du Rhin - BP 60024 -
67401 Illkirch cedex – France.
Tel : + 33 (0)3 68 85 42 03
Fax : + 33 (0)3 68 85 43 06
E-mail : pons@unistra.fr

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(mise en ligne, 09 juin 2016)